Differentiating constrictive pericarditis and restrictive cardiomyopathy
- Paul Sorajja, MD
Paul Sorajja, MD
- Director, Center for Valve and Structural Heart Disease
- Minneapolis Heart Institute
- Brian D Hoit, MD
Brian D Hoit, MD
- Professor of Medicine and Physiology and Biophysics
- Case Western Reserve University and University Hospitals of Cleveland
Constrictive pericarditis is the result of scarring and consequent loss of the normal elasticity of the pericardial sac. This leads to impairment of ventricular filling in mid and late diastole. As a result, the majority of ventricular filling occurs rapidly in early diastole and the ventricular volume does not increase after the end of the early filling period.
Restrictive cardiomyopathy is characterized by a nondilated rigid ventricle, resulting in severe diastolic dysfunction and restrictive filling that produces hemodynamic changes similar to those in constrictive pericarditis.
Constrictive pericarditis and restrictive cardiomyopathy both lead to diastolic heart failure with normal (or near normal) systolic function, and characteristically abnormal ventricular filling that results in similar clinical and hemodynamic features. However, because of their markedly different treatments, differentiating between the two conditions is critical. In some patients, the correct diagnosis may be readily suggested from the history or routine diagnostic testing. In others, however, this differentiation cannot be diagnosed before biopsy or even surgical exploration.
The distinction between constrictive pericarditis and restrictive cardiomyopathy will be reviewed here. The basic aspects of constrictive pericarditis and idiopathic restrictive cardiomyopathy are discussed separately. (See "Constrictive pericarditis" and "Idiopathic restrictive cardiomyopathy".)
PATHOPHYSIOLOGY OF RESPIRATORY EFFECTS
An understanding of ventricular volume constraints and ventricular interaction is key in any discussion of the hemodynamic differences between constrictive pericarditis and restrictive cardiomyopathy.To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- PATHOPHYSIOLOGY OF RESPIRATORY EFFECTS
- HISTORY AND PHYSICAL EXAMINATION
- Physical examination
- NON-INVASIVE TESTING
- Plasma BNP
- Chest radiography
- Pericardial imaging
- Doppler echocardiography
- Tissue Doppler imaging
- Speckle tracking echocardiography (STE)
- Cardiac magnetic resonance (CMR)
- CARDIAC CATHETERIZATION
- SUMMARY AND RECOMMENDATIONS