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Diagnosis of epidermolysis bullosa

Anna L Bruckner, MD
Dedee F Murrell, MD
Section Editor
Jonathan A Dyer, MD
Deputy Editor
Rosamaria Corona, MD, DSc


Epidermolysis bullosa (EB) includes a heterogeneous group of inherited disorders with the common finding of epithelial fragility. The skin, and in some cases the mucosa, develops blisters and/or erosions in response to minimal frictional trauma. Four major EB types are recognized on the basis of the ultrastructural level of skin cleavage (figure 1):

EB simplex (intraepidermal)

Junctional EB (intra-lamina lucida)

Dystrophic EB (sub-lamina densa)

Kindler syndrome (intraepidermal, intra-lamina lucida, and sub-lamina densa)


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Literature review current through: Sep 2016. | This topic last updated: Aug 18, 2015.
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