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Determinants of glucocorticoid dosing

Daniel E Furst, MD
Kenneth G Saag, MD, MSc
Section Editor
Eric L Matteson, MD, MPH
Deputy Editor
Monica Ramirez Curtis, MD, MPH


Natural and synthetic glucocorticoids (also called steroids) can be used for a variety of disorders. These agents are most commonly given in pharmacologic doses to manage conditions that require the suppression of inflammation. Less often, they are used to establish the diagnosis and cause of Cushing's syndrome and for hormone replacement in adrenal insufficiency and congenital adrenal hyperplasia.

The determinants of glucocorticoid dosing include:

Pharmacokinetics of the different drug preparations

Effects of underlying disorders on drug kinetics

Interactions of glucocorticoids with concurrently administered non-glucocorticoid drugs

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Literature review current through: Nov 2017. | This topic last updated: Apr 01, 2016.
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