Determinants of glucocorticoid dosing
- Daniel E Furst, MD
Daniel E Furst, MD
- Section Editor — Treatment Issues in Rheumatology
- Professor of Rheumatology, University of Washington, Seattle
- Professor of Rheumatology, Washington University of Florence, Florence, Italy
- Professor of Rheumatology, University of California in Los Angeles (Emeritus)
- Director of Research, Pacific
- Kenneth G Saag, MD, MSc
Kenneth G Saag, MD, MSc
- Professor of Medicine
- University of Alabama at Birmingham
Natural and synthetic glucocorticoids (also called steroids) can be used for a variety of disorders. These agents are most commonly given in pharmacologic doses to manage conditions that require the suppression of inflammation. Less often, they are used to establish the diagnosis and cause of Cushing's syndrome and for hormone replacement in adrenal insufficiency and congenital adrenal hyperplasia.
The determinants of glucocorticoid dosing include:
●Pharmacokinetics of the different drug preparations
●Effects of underlying disorders on drug kinetics
●Interactions of glucocorticoids with concurrently administered non-glucocorticoid drugs
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- BIOEQUIVALENCE AND BIOAVAILABILITY
- Inhaled glucocorticoids
- Distribution in breast milk
- DISEASES AND ALTERED PHYSIOLOGIC STATES
- Cystic fibrosis
- End-stage renal disease
- Inflammatory bowel disease
- Nephrotic syndrome
- Severe liver disease
- DRUG INTERACTIONS
- Systemic glucocorticoids
- Inhaled or intranasal glucocorticoids
- SUMMARY AND RECOMMENDATIONS