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Denosumab for osteoporosis

Author
Harold N Rosen, MD
Section Editor
Clifford J Rosen, MD
Deputy Editor
Jean E Mulder, MD

INTRODUCTION

Denosumab is a fully human monoclonal antibody to the receptor activator of nuclear factor kappaB ligand (RANKL), an osteoclast differentiating factor. It inhibits osteoclast formation, decreases bone resorption, increases bone mineral density (BMD), and reduces the risk of fracture.

This topic review will discuss the use of denosumab as a therapy for osteoporosis. Other treatments for osteoporosis are reviewed in detail elsewhere.

(See "Overview of the management of osteoporosis in postmenopausal women".)

(See "Treatment of osteoporosis in men".)

(See "The use of bisphosphonates in postmenopausal women with osteoporosis".)

                      

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Literature review current through: Nov 2016. | This topic last updated: Tue May 31 00:00:00 GMT+00:00 2016.
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References
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