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Cyclic vomiting syndrome

David J Desilets, MD, PhD
Section Editors
Nicholas J Talley, MD, PhD
Marc C Patterson, MD, FRACP
George D Ferry, MD
Deputy Editor
Shilpa Grover, MD, MPH


Cyclic vomiting syndrome (CVS) is an idiopathic disorder characterized by recurrent, stereotypical bouts of vomiting with intervening periods of normal health [1]. Although it appears to primarily affect children, it is being recognized increasingly in adults.

CVS was first described in France in 1861 [2]. The first English-language publication, in 1882, described three essential clinical features of the disorder, which still hold true today [3]:

Three or more recurrent discrete episodes of vomiting

Varying intervals of completely normal health between episodes

Episodes are stereotypical with regard to timing of onset, symptoms, and duration


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Literature review current through: Sep 2016. | This topic last updated: May 17, 2016.
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