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Cutaneous T cell pseudolymphomas

Author
Rein Willemze, MD
Section Editor
John A Zic, MD
Deputy Editor
Rosamaria Corona, MD, DSc

INTRODUCTION

The term cutaneous pseudolymphoma refers to a heterogeneous group of benign skin disorders that simulate cutaneous lymphomas histologically and sometimes clinically. Cutaneous pseudolymphomas can be separated into two major subtypes, pseudolymphomas mimicking a cutaneous B cell lymphoma and pseudolymphomas mimicking a cutaneous T cell lymphoma (table 1) [1,2].

Histologically, cutaneous T cell pseudolymphomas may show a superficial band-like pattern simulating early patch/plaque-stage mycosis fungoides (MF) or a nodular or diffuse pattern simulating peripheral T cell lymphoma, not otherwise specified (PTCL, NOS) or tumor-stage MF. Examples of the first category include lymphomatoid contact dermatitis, lymphomatoid drug eruptions, and actinic reticuloid; examples of the second category include persistent arthropod reactions and nodular scabies. However, in most cases the cause is unknown. Such idiopathic cutaneous pseudo-T-cell lymphomas may have a band-like superficial pattern or a nodular or diffuse pattern.

This topic will focus on distinct clinicopathologic entities commonly included in the spectrum of cutaneous T cell pseudolymphomas. Other mimickers of early-stage MF or primary cutaneous CD30+ lymphoproliferative disorders, as well as HIV- and other immunodeficiency-related CD8+ cutaneous pseudolymphomas will be briefly discussed. Cutaneous T cell lymphomas, lymphomatoid papulosis, and cutaneous B cell pseudolymphomas are discussed separately.

(See "Clinical manifestations, pathologic features, and diagnosis of mycosis fungoides".)

(See "Clinical presentation, pathologic features, and diagnosis of Sézary syndrome".)

                         

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Literature review current through: Nov 2016. | This topic last updated: Thu Aug 27 00:00:00 GMT+00:00 2015.
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