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Medline ® Abstract for Reference 94

of 'Cutaneous side effects of conventional chemotherapy agents'

94
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Fixed erythrodysaesthesia plaque due to intravenous injection of docetaxel.
AU
Chu CY, Yang CH, Yang CY, Hsiao GH, Chiu HC
SO
Br J Dermatol. 2000;142(4):808.
 
Docetaxel (Taxotere), a semisynthetic taxoid, acts as an antimicrotubule agent and is considered to have great potential in the treatment of non-small cell lung cancer, advanced breast cancer, ovarian cancer and some other tumours. Well-recognized side-effects include dose-limiting neutropenia, fluid retention, myalgia, neuropathy, hypersensitivity reaction, alopecia, mucositis, nail changes and cutaneous reactions such as acral erythema. We describe a unique docetaxel-induced cutaneous reaction presenting as fixed erythematous plaque(s) unrelated to extravasation or previous skin injury; histopathological studies were performed in three of the four cases.
AD
Departments of Dermatology and Oncology, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan.
PMID