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Medline ® Abstract for Reference 94

of 'Cutaneous side effects of conventional chemotherapy agents'

Fixed erythrodysaesthesia plaque due to intravenous injection of docetaxel.
Chu CY, Yang CH, Yang CY, Hsiao GH, Chiu HC
Br J Dermatol. 2000;142(4):808.
Docetaxel (Taxotere), a semisynthetic taxoid, acts as an antimicrotubule agent and is considered to have great potential in the treatment of non-small cell lung cancer, advanced breast cancer, ovarian cancer and some other tumours. Well-recognized side-effects include dose-limiting neutropenia, fluid retention, myalgia, neuropathy, hypersensitivity reaction, alopecia, mucositis, nail changes and cutaneous reactions such as acral erythema. We describe a unique docetaxel-induced cutaneous reaction presenting as fixed erythematous plaque(s) unrelated to extravasation or previous skin injury; histopathological studies were performed in three of the four cases.
Departments of Dermatology and Oncology, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan.