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Medline ® Abstract for Reference 83

of 'Cutaneous side effects of conventional chemotherapy agents'

Palmar-plantar erythrodysesthesia associated with scrotal and penile involvement with capecitabine.
Sapp CM, DeSimone P
Clin Colorectal Cancer. 2007;6(5):382.
Capecitabine is an orally active fluoropyrimidine that has been approved for first-line treatment of metastatic colorectal cancer when fluoropyrimidines alone are indicated. One of the toxicities described in the literature associated with capecitabine is palmar-plantar erythrodysesthesia. Based on a careful review of the literature, no reported cases of erythema, ulceration, and swelling that involves the penis and scrotum have been described in association with capecitabine. The following 2 cases illustrate palmar-plantar erythrodysesthesia with scrotal and penile involvement secondary to capecitabine.
University of Kentucky, Markey Cancer Center, Lexington, KY 40536-0093, USA.