Medline ® Abstract for Reference 50
of 'Cutaneous side effects of conventional chemotherapy agents'
Baran R, Juhlin L
Photodermatol Photoimmunol Photomed. 2002;18(4):202.
BACKGROUND/PURPOSE: Photoonycholysis may be seen as a part of Segal's triad, photosensitivity followed by discoloration of the nails and onycholysis. But the latter may also appear, independently, in the absence of photosensitive reaction elsewhere.
METHODS: Photoonycholysis may result from drug intake, porphyria cutanea tarda, erythropoietic porphyria, erythropoietic protoporphyria, variegate porphyria and pseudoporphyria. Rarely, spontaneous photoonycholysis may be observed.
RESULTS: Four distinct subtypes have been recorded without relationship between the responsible drugs and the different clinical varieties of photoonycholysis. Primary photohemorrhage can occur; it can also be associated with polydactylous photoonycholysis type III.
CONCLUSION: The inability to reproduce photoonycholysis experimentally should be emphasized.
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