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Medline ® Abstract for Reference 32

of 'Cutaneous side effects of conventional chemotherapy agents'

Nail disorders in a woman treated with ixabepilone for metastatic breast cancer.
Alimonti A, Nardoni C, Papaldo P, Ferretti G, Caleno MP, Carlini P, Fabi A, Rasio D, Vecchione A, Cognetti F
Anticancer Res. 2005;25(5):3531.
Ixabepilone (Ix) (BMS-247550) is a potent member of a new class of microtubule-stabilizing cytotoxic agents known as epothilones. In pre-clinical studies, Ix has shown anticancer activity against several cancer types, including paclitaxel-resistant models, both in vitro and in vivo. The major toxicities associated with Ix are myelosuppression, sensory neuropathy and neutropenia. Other minor side-effects include asthenia/fatigue, stomatitis, anorexia, alopecia, skin reaction, hypersensitivity reactions and a fluid-retention syndrome. Although Ix is functionally correlated to taxanes, no previous evidence exists regarding Ix-related nail disorders. Here, we report a case of a 59-year-old woman treated with Ix at 40 mg/m2 day 1 q 21 days who, after 8 cycles of therapy, developed onycholysis and subungual hemorrhagic bullas in the fingernails.
Division of Medical Oncology A, Regina Elena Cancer Institute, Rome, Italy. alimonta@mskcc.org