Medline ® Abstract for Reference 21
of 'Cutaneous side effects of conventional chemotherapy agents'
Nail pigmentation caused by hydroxyurea: report of 9 cases.
Aste N, Fumo G, Contu F, Aste N, Biggio P
J Am Acad Dermatol. 2002;47(1):146.
We report a series of 9 patients, 6 men and 3 women, who presented nail hyperpigmentation arising between 6 and 24 months from the start of hydroxyurea therapy. The most commonly observed clinical pattern was that of longitudinal melanonychia. In only 1 patient, who was affected in all 20 nails, we observed longitudinal melanonychia, diffuse melanonychia, and hyperpigmentation of the skin.
Department of Dermatology, Ospedale S. Giovanni de Dio, University of Cagliari, Via Ospedale 54, 09124-Cagliari, Italy.