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Medline ® Abstract for Reference 156

of 'Cutaneous side effects of conventional chemotherapy agents'

Hydroxyurea-induced leg ulceration in 14 patients.
Best PJ, Daoud MS, Pittelkow MR, Petitt RM
Ann Intern Med. 1998;128(1):29.
BACKGROUND: Hydroxyurea is an antineoplastic agent commonly used to treat myeloproliferative disorders and other nonneoplastic conditions.
OBJECTIVE: To further define the typical features of hydroxyurea-related cutaneous ulcers of the leg.
DESIGN: Retrospective, descriptive study of the medical records of patients who developed leg ulcers while receiving hydroxyurea therapy.
SETTING: A tertiary care medical center.
PATIENTS: Patients with myeloproliferative disorders who were treated with hydroxyurea.
RESULTS: 14 patients with extremely painful leg ulcers were identified. The most common ulcer site was the malleoli. Multiple ulcers were seen in 64% of patients. Patients had received hydroxyurea for an average of 6 years before ulcers developed. All ulcers healed after discontinuation of hydroxyurea treatment, and 2 patients developed ulcers after treatment was restarted.
CONCLUSION: Hydroxyurea induces painful leg ulcers that are usually difficult to treat and require cessation of hydroxyurea therapy.
Mayo Clinic, Rochester, Minnesota, USA.