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Medline ® Abstract for Reference 6

of 'Cutaneous manifestations of internal malignancy'

Malignant Acanthosis Nigricans Associated with Ovarian Cancer.
Oh CW, Yoon J, Kim CY
Case Rep Dermatol. 2010;2(2):103. Epub 2010 Jul 2.
Malignant acanthosis nigricans is a cutaneous eruption characterized by symmetric hyperpigmented hyperkeratosis, dermal papillomatosis, and mucosal involvement associated with internal malignancies. Tripe palms refers to a characteristic velvety thickening of the palms, with exaggeration of normal skin markings. We present the second case of ovarian cancer in association with two coexisting paraneoplastic dermatoses occurring in a 57-year-old Korean female. The presence of acanthosis nigricans in conjunction with tripe palms in a female patient is highly suggestive of an internal malignancy including an ovarian cancer and demands an extensive search for the hidden ovarian cancer.
Department of Dermatology, School of Medicine, Kangwon National University Hospital, Hyoja-dong, Chuncheon, Korea.