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Medline ® Abstract for Reference 27

of 'Cutaneous manifestations of internal malignancy'

Acquired ichthyosis in bone marrow transplant recipients.
Spelman LJ, Strutton GM, Robertson IM, Weedon D
J Am Acad Dermatol. 1996;35(1):17.
BACKGROUND: Acquired ichthyosis (AI) has been described in a variety of clinical situations. We have observed cases of ichthyosis in bone marrow transplant recipients.
OBJECTIVE: Our purpose was to characterize these changes clinically and histologically and to compare them with other cases of acquired ichthyosis.
METHODS: Skin biopsy specimens were taken before transplantation and from affected areas after transplantation.
RESULTS: AI was observed in four patients who had received a bone marrow transplant for leukemia. None of the patients had a previous personal or family history of ichthyosis. In all patients graft-versus-host disease developed after transplantation. The eruption clinically and histologically most closely resembled ichthyosis vulgaris. The ichthyotic changes appeared to be unrelated to specific drug therapy.
CONCLUSION: AI is a previously unreported cutaneous complication of bone marrow transplantation.It may be related to graft-versus-host disease in these patients.
Department of Dermatology, Royal Brisbane Hospital, Australia.