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Medline ® Abstract for Reference 23

of 'Cutaneous manifestations of internal malignancy'

Acquired ichthyosis.
Patel N, Spencer LA, English JC 3rd, Zirwas MJ
J Am Acad Dermatol. 2006 Oct;55(4):647-56.
Acquired ichthyosis (AI) is a nonhereditary cutaneous disorder characterized by dry, rough skin with prominent scaling that involves significant portions of the body. It has been associated with malignancies; autoimmune/inflammatory, metabolic, endocrine, and infectious diseases; and medication use. Most microscopic studies of AI exhibit hyperkeratosis with a reduced or absent granular layer. Because AI has been linked to a variety of conditions, the workup of a patient presenting with this finding can be complex. We present an update on AI to provide clinicians with direction regarding the assessment and treatment of patients presenting with AI. An algorithm for the evaluation of patients presenting with AI is provided.
Georgetown University School of Medicine, Washington, USA.