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Cutaneous manifestations of amyloidosis

Kim Bohjanen, MD
Daniel D. Miller, MD
Section Editor
Jeffrey Callen, MD, FACP, FAAD
Deputy Editor
Abena O Ofori, MD


Amyloidosis is the abnormal deposition of amyloid (insoluble fibrils comprised of beta-pleated sheets of protein) in extracellular tissues. Amyloid appears microscopically as globules of eosinophilic, homogeneous, hyaline material.

The deposition of amyloid in the skin can occur as a skin-limited disorder (primary localized cutaneous amyloidosis and secondary localized cutaneous amyloidosis). Cutaneous amyloidosis may also occur as a manifestation of systemic amyloidosis, most often in immunoglobulin light chain (AL) amyloidosis.

The clinical manifestations, diagnosis, and management of cutaneous amyloidosis, with a focus on primary localized cutaneous amyloidosis, will be reviewed here. Systemic amyloidosis is reviewed in detail separately.

(See "Overview of amyloidosis".)

(See "Pathogenesis of immunoglobulin light chain (AL) amyloidosis and light and heavy chain deposition diseases".)


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Literature review current through: Dec 2016. | This topic last updated: Thu Oct 20 00:00:00 GMT 2016.
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