Cutaneous B cell pseudolymphomas
- Rein Willemze, MD
Rein Willemze, MD
- Professor and Chairman, Department of Dermatology
- Leiden University Medical Center
The term cutaneous pseudolymphoma refers to a heterogeneous group of benign skin disorders that simulate cutaneous lymphomas histologically and sometimes clinically. Cutaneous pseudolymphomas can be separated into two major subtypes, pseudolymphomas mimicking a cutaneous B cell lymphoma (B cell pseudolymphomas) and pseudolymphomas mimicking a cutaneous T cell lymphoma (T cell pseudolymphomas) (table 1) [1-3].
Cutaneous B cell pseudolymphomas (previously called lymphadenosis benigna cutis, lymphocytoma cutis, pseudolymphoma of Spiegler-Fendt, or cutaneous lymphoid hyperplasia) represent a reactive B-cell proliferation response to a variety of antigenic stimuli, including arthropod bites, gold pierced earrings, tattoo dyes, and drugs. They usually present as erythematous nodules or plaques that simulate indolent primary cutaneous B cell lymphomas, in particular primary cutaneous marginal zone lymphoma (PCMZL) or primary cutaneous follicle center lymphoma (PCFCL).
This topic will discuss the pathogenesis, clinical presentation, and differential diagnosis of B cell pseudolymphomas. Primary cutaneous B cell lymphomas, cutaneous T cell pseudolymphomas, and lymphomatoid papulosis are discussed separately.To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- ETIOLOGY AND PATHOGENESIS
- CLINICAL PRESENTATION
- Clinical course
- Clonality analysis
- DIFFERENTIAL DIAGNOSIS
- Primary cutaneous marginal zone lymphoma
- - Are cutaneous B cell pseudolymphoma and PCMZL a disease spectrum?
- Primary cutaneous follicle center lymphoma
- Secondary cutaneous follicular lymphoma
- SUMMARY AND RECOMMENDATIONS