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Cushing's syndrome due to primary bilateral macronodular adrenal hyperplasia

Author
André Lacroix, MD
Section Editor
Lynnette K Nieman, MD
Deputy Editor
Kathryn A Martin, MD

INTRODUCTION

Among the causes of Cushing's syndrome are three rare types of nodular adrenocortical diseases that are usually bilateral:

Corticotropin (ACTH)-dependent bilateral macronodular hyperplasia, secondary to long-term adrenal stimulation in patients with Cushing's disease or ectopic ACTH syndrome.

ACTH-independent micronodular adrenal hyperplasia and its most frequent variant, primary pigmented nodular adrenocortical disease (PPNAD), which may be sporadic or familial (as part of the Carney complex).

Primary bilateral macronodular adrenal hyperplasia (BMAH), a disorder previously referred to as ACTH-independent bilateral macronodular adrenal hyperplasia (AIMAH).

BMAH will be reviewed here. Other causes of Cushing's syndrome, and PPNAD, are discussed separately. (See "Causes and pathophysiology of Cushing's syndrome" and "Cushing's syndrome due to primary pigmented nodular adrenocortical disease".)

                           

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Literature review current through: Nov 2016. | This topic last updated: Wed Dec 17 00:00:00 GMT+00:00 2014.
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