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Medline ® Abstract for Reference 48

of 'Critical illness during pregnancy and the peripartum period'

Herpes simplex hepatitis in pregnancy: a case report and review of the literature.
Kang AH, Graves CR
Obstet Gynecol Surv. 1999;54(7):463.
Fulminant hepatic dysfunction in the third trimester of pregnancy accompanied by fever may result from disseminated herpes simplex virus. Since 1969, 24 cases of herpes simplex hepatitis, including the current case, have been reported. Mucocutaneous lesions are present in only half of cases; therefore, suspicion for diagnosis of this disease is low. Twenty-five percent of cases were not diagnosed until autopsy. Maternal and perinatal mortality are high, approaching 39 percent for both mother and fetus. Early recognition with initiation of antiviral therapy appears to be most important in maximizing survival.
Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, Tennessee 37232, USA.