- Namita Roy-Chowdhury, PhD
Namita Roy-Chowdhury, PhD
- Professor of Medicine and Genetics
- Albert Einstein College of Medicine
- Jayanta Roy-Chowdhury, MD, MRCP
Jayanta Roy-Chowdhury, MD, MRCP
- Professor of Medicine and Genetics
- Albert Einstein College of Medicine
- Section Editors
- Elizabeth B Rand, MD
Elizabeth B Rand, MD
- Section Editor — Pediatric Hepatology
- Associate Professor of Pediatrics
- University of Pennsylvania School of Medicine
- Keith D Lindor, MD
Keith D Lindor, MD
- Section Editor — Alcoholic and Metabolic Liver Disease
- Professor of Medicine, Mayo Clinic College of Medicine
- Executive Vice Provost and Dean, Health Solutions
- Arizona State University
●Uptake from the circulation
●Conjugation with glucuronic acid
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- Sauter BV, Parashar B, Chowdhury NR, et al. A replication-deficient rSV40 mediates liver-directed gene transfer and a long-term amelioration of jaundice in gunn rats. Gastroenterology 2000; 119:1348.
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- TYPE I DISEASE
- Molecular defect
- Clinical manifestations and diagnosis
- - Distinction from type II disease
- - Phototherapy
- - Plasmapheresis
- - Calcium phosphate supplementation
- - Orlistat
- - Inhibition of bilirubin production
- - Liver transplantation
- - Hepatocyte transplantation
- Gene therapy
- - Ex vivo gene transduction
- - Vector-mediated gene delivery
- - Adenoviral vectors
- - SV40 and lentiviruses
- - Receptor-mediated gene delivery to the liver
- - Site-directed gene conversion
- TYPE II DISEASE
- Molecular defect
- SUMMARY AND RECOMMENDATIONS