- Namita Roy-Chowdhury, PhD
Namita Roy-Chowdhury, PhD
- Professor of Medicine and Genetics
- Albert Einstein College of Medicine
- Jayanta Roy-Chowdhury, MD, MRCP
Jayanta Roy-Chowdhury, MD, MRCP
- Professor of Medicine and Genetics
- Albert Einstein College of Medicine
- Section Editors
- Elizabeth B Rand, MD
Elizabeth B Rand, MD
- Section Editor — Pediatric Hepatology
- Associate Professor of Pediatrics
- University of Pennsylvania School of Medicine
- Keith D Lindor, MD
Keith D Lindor, MD
- Section Editor — Alcoholic and Metabolic Liver Disease
- Professor of Medicine, Mayo Clinic College of Medicine
- Dean, College of Health Solutions
- Arizona State University
●Uptake from the circulation
●Conjugation with glucuronic acid
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- Ilan Y, Roy-Chowdhury N, Prakash R, et al. Massive repopulation of rat liver by transplantation of hepatocytes into specific lobes of the liver and ligation of portal vein branches to other lobes. Transplantation 1997; 64:8.
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- Sauter BV, Parashar B, Chowdhury NR, et al. A replication-deficient rSV40 mediates liver-directed gene transfer and a long-term amelioration of jaundice in gunn rats. Gastroenterology 2000; 119:1348.
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- TYPE I DISEASE
- Molecular defect
- Clinical manifestations and diagnosis
- - Distinction from type II disease
- - Phototherapy
- - Plasmapheresis
- - Calcium phosphate supplementation
- - Orlistat
- - Inhibition of bilirubin production
- - Liver transplantation
- - Hepatocyte transplantation
- Gene therapy
- - Ex vivo gene transduction
- - Vector-mediated gene delivery
- - Adenoviral vectors
- - SV40 and lentiviruses
- - Receptor-mediated gene delivery to the liver
- - Site-directed gene conversion
- TYPE II DISEASE
- Molecular defect
- SUMMARY AND RECOMMENDATIONS