Corticotropin-releasing hormone stimulation test
- Lynnette K Nieman, MD
Lynnette K Nieman, MD
- Section Editor — Adrenal Disease
- Senior Investigator
- Bethesda, MD
Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide that is the major physiologic corticotropin (ACTH) secretagogue . There is considerable sequence homology of CRH among species, particularly in the amino-terminal region, which is required for biologic activity. As a result, both ovine and human sequences are used in endocrine testing to:
●Evaluate the cause of ACTH-dependent Cushing's syndrome (with or without vasopressin analogs).
●Discriminate between pseudo-Cushing's and Cushing's syndrome.
●Discriminate between pituitary or hypothalamic localization of central adrenal insufficiency.
●To assess ACTH suppression in patients suspected of primary adrenal mild Cushing's syndrome when basal ACTH levels are incompletely suppressed between 5 and 15 pg/mL [1.1 to 3.3 pmol/L]. (See "Cushing's syndrome due to primary bilateral macronodular adrenal hyperplasia".)To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- CORTICOTROPIN-RELEASING HORMONE STIMULATION TEST
- Normal values
- CRH PLUS ARGININE VASOPRESSIN OR DESMOPRESSIN
- DIAGNOSIS OF THE CAUSE OF CUSHING'S SYNDROME
- CRH stimulation test
- CRH plus arginine vasopressin stimulation test
- CRH plus desmopressin stimulation test
- Caveats to the use of CRH, AVP or desmopressin in Cushing's syndrome
- CRH AFTER TRANSSPHENOIDAL SURGERY TO PREDICT RECURRENCE
- CRH AFTER LOW-DOSE DEXAMETHASONE TEST
- ADRENAL INSUFFICIENCY
- SOCIETY GUIDELINE LINKS