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Medline ® Abstract for Reference 8

of 'Congenital rubella syndrome: Management, outcome, and prevention'

A fifty-year follow-up of congenital rubella.
McIntosh ED, Menser MA
Lancet. 1992;340(8816):414.
50 patients with congenital rubella, born in 1939-43, were reviewed in 1967. Here we report their outcome in 1991. Since 1967, there have been 7 deaths (3 cardiovascular, 3 malignant disease, 1 AIDS). 40 had full clinical assessment. The prevalence of diabetes mellitus is similar to that in 1967: 4 of the 5 reported diabetic then, remain so, and there is 1 new case. 1 subject has malignant melanoma and 3 have died from cancer. Although the incidence of malignant disease is not increased, the death rate is (standardised mortality rate 6.0, 95% CI 1.24-17.57). Longer follow-up will be required to confirm this observation.
Department of Medicine, Royal Alexandra Hospital for Children, Camperdown, NSW, Australia.