Congenital melanocytic nevi
- Julie V Schaffer, MD
Julie V Schaffer, MD
- Attending in Pediatric Dermatology
- Director, Pediatric Dermatology Fellowship
- Division of Pediatric & Adolescent Dermatology
- Hackensack University Medical Center
- Jean L Bolognia, MD
Jean L Bolognia, MD
- Professor of Dermatology
- Yale University School of Medicine
- Section Editors
- Moise L Levy, MD
Moise L Levy, MD
- Section Editor — Pediatric Dermatology
- Professor of Pediatrics and Medicine (Dermatology)
- Dell Medical School, University of Texas, Austin
- Clinical Professor of Dermatology and Pediatrics
- Baylor College of Medicine
- Hensin Tsao, MD, PhD
Hensin Tsao, MD, PhD
- Section Editor — Melanocytic Lesions and Disorders of Pigmentation
- Professor of Dermatology
- Harvard Medical School
Melanocytic nevi (moles) represent benign proliferations of a type of melanocyte known as a "nevus cell." The two major differences between ordinary melanocytes that reside in the basal layer of the epidermis and nevus cells are:
●Nevus cells cluster as nests within the lower epidermis and/or dermis, whereas epidermal melanocytes are evenly dispersed as single units
●Nevus cells do not have dendritic processes (with the exception of those within blue nevi)
Both melanocytes and nevus cells are capable of producing the pigment melanin. Melanocytic nevi can be congenital or acquired. Congenital melanocytic nevi (CMN) are classically defined as melanocytic nevi present at birth or within the first few months of life.
CMN and speckled lentiginous nevi (a subtype of CMN) will be discussed below. Acquired melanocytic nevi and other benign pigmented skin lesions are discussed separately. (See "Acquired melanocytic nevi (moles)" and "Benign pigmented skin lesions other than melanocytic nevi (moles)".)
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- CLINICAL FEATURES
- DERMOSCOPIC FEATURES
- NATURAL HISTORY
- Proliferative nodules
- Neurocutaneous melanosis
- Other malignancies
- Small/medium CMN
- Large CMN
- Surveillance for neurocutaneous melanosis
- SPECKLED LENTIGINOUS NEVUS
- SUMMARY AND RECOMMENDATIONS