Medline ® Abstract for Reference 187
of 'Complementary and alternative therapies for cancer'
Urothelial malignant disease and Chinese herbal nephropathy.
Lord GM, Cook T, Arlt VM, Schmeiser HH, Williams G, Pusey CD
We have previously reported occurrence of a specific type of nephropathy due to ingestion of Chinese herbs (Chinese herbal nephropathy [CHN]) in two patients in the UK. These cases highlighted the role of aristolochic acid in causing this nephropathy, which was first described in a Belgian cohort. We now report development of invasive transitional cell carcinoma of the urinary tract associated with the presence of aristolochic acid-DNA adducts in one of these patients. This work clearly shows the carcinogenic potential of aristolochic acid in this new type of nephropathy.