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Medline ® Abstract for Reference 187

of 'Complementary and alternative therapies for cancer'

187
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Urothelial malignant disease and Chinese herbal nephropathy.
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Lord GM, Cook T, Arlt VM, Schmeiser HH, Williams G, Pusey CD
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Lancet. 2001;358(9292):1515.
 
We have previously reported occurrence of a specific type of nephropathy due to ingestion of Chinese herbs (Chinese herbal nephropathy [CHN]) in two patients in the UK. These cases highlighted the role of aristolochic acid in causing this nephropathy, which was first described in a Belgian cohort. We now report development of invasive transitional cell carcinoma of the urinary tract associated with the presence of aristolochic acid-DNA adducts in one of these patients. This work clearly shows the carcinogenic potential of aristolochic acid in this new type of nephropathy.
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PMID