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Comorbidities and complications of type 2 diabetes mellitus in children and adolescents

Lori Laffel, MD, MPH
Britta Svoren, MD
Section Editor
Joseph I Wolfsdorf, MB, BCh
Deputy Editor
Alison G Hoppin, MD


Children and adolescents with type 2 diabetes mellitus (T2DM) are at increased risk for associated comorbidities that include:



Nonalcoholic fatty liver disease (NAFLD)

Adult patients with T2DM, especially those with poor glycemic control, hypertension, and dyslipidemia, are at increased risk for vascular complications. Although data in children and adolescents with T2DM are limited, they suggest that children and adolescents are also at increased risk for vascular disease similar to that seen in adults with T2DM [1]. Further, a large prospective study (TODAY study) provides data on the occurrence of comorbidities and complications in youth-onset T2DM [2,3]. Glycemic control among adolescents with T2DM is often poor. Studies in several populations report that less than half of the adolescents with type 2 diabetes regularly attend follow-up visits [1]. One study reported mean glycated hemoglobin concentrations of 12 percent, even among patients involved in active follow-up [4].


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Literature review current through: Jan 2016. | This topic last updated: Jan 2, 2015.
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