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Cogan’s syndrome

INTRODUCTION

Cogan’s syndrome (CS) is a chronic inflammatory disorder that most commonly affects young adults. Clinical hallmarks are interstitial keratitis (IK) and vestibuloauditory dysfunction [1]. Associations between CS and systemic vasculitis, as well as aortitis, also exist [2-4].

The pathology, pathogenesis, clinical manifestations, and treatment of CS will be presented here.

PATHOLOGY

Limited autopsy data derived from temporal bone specimens of patients with Cogan’s syndrome (CS) reveal a range of findings, including [5-7]:

Lymphocyte and plasma cell infiltration of the spiral ligament

Endolymphatic hydrops

                  

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Literature review current through: Oct 2014. | This topic last updated: Mar 10, 2014.
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References
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