Medline ® Abstract for Reference 81
of 'Clostridium difficile infection in adults: Clinical manifestations and diagnosis'
Evaluation of diagnostic tests for Clostridium difficile infection.
Swindells J, Brenwald N, Reading N, Oppenheim B
J Clin Microbiol. 2010;48(2):606. Epub 2009 Dec 23.
We evaluated toxigenic Clostridium difficile detection by a lateral flow assay for antigen and toxin, an enzyme immunoassay, and two commercial PCR methods. Compared to the cell cytotoxicity neutralization assay and toxigenic culture, both toxin detection methods lacked sensitivity. PCR following combined antigen and toxin detection provided the most useful diagnostic information.
Department of Microbiology, City Hospital, Dudley Road, Birmingham, United Kingdom.