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Medline ® Abstract for Reference 64

of 'Clostridium difficile infection in adults: Clinical manifestations and diagnosis'

Is repeat PCR needed for diagnosis of Clostridium difficile infection?
Luo RF, Banaei N
J Clin Microbiol. 2010;48(10):3738. Epub 2010 Aug 4.
Patients with diarrhea, defined as loose or watery stool, and two or more Clostridium difficile tcdB PCR tests within 14 days of each other were investigated. Repeat PCR for 293 patients with a prior negative result yielded negative results in 396 (97.5%) of 406 tests. Ten new positives were detected, including one false positive. Repeat PCR within 7 days appears rarely useful, except for patients with evidence of a new infection.
Stanford University School of Medicine, Department of Pathology, Palo Alto, CA 94304, USA. rluo2@stanford.edu