Medline ® Abstract for Reference 62
of 'Clostridium difficile infection in adults: Clinical manifestations and diagnosis'
Rapid and reliable diagnostic algorithm for detection of Clostridium difficile.
Fenner L, Widmer AF, Goy G, Rudin S, Frei R
J Clin Microbiol. 2008;46(1):328. Epub 2007 Nov 21.
We evaluated a two-step algorithm for detection of Clostridium difficile in 1,468 stool specimens. First, specimens were screened by an immunoassay for C. difficile glutamate dehydrogenase antigen (C.DIFF CHEK-60). Second, screen-positive specimens underwent toxin testing by a rapid toxin A/B assay (TOX A/B QUIK CHEK); toxin-negative specimens were subjected to stool culture. This algorithm allowed final results for 92% of specimens with a turnaround time of 4 h.
Microbiology Laboratory, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.