Medline ® Abstract for Reference 98
of 'Clostridium difficile in adults: Treatment'
Gamma globulin administration in relapsing Clostridium difficile-induced pseudomembranous colitis with a defective antibody response to toxin A.
Warny M, Denie C, Delmée M, Lefebvre C
Acta Clin Belg. 1995;50(1):36.
A 53-year-old woman suffered six episodes of Clostridium difficile-pseudomembranous colitis. The serological follow-up demonstrated the absence of a rise in IgG and IgA to toxin A. Human pooled gamma globulin was administered during the fifth relapse and raised IgG levels to toxin A. Normal stools reappeared a week later. The role of the antibodies to toxin A and gamma globulin in C. difficile colitis are discussed.
Département de Microbiologie, UniversitéCatholique de Louvain, Bruxelles, Belgique.