Medline ® Abstract for Reference 81
of 'Clostridium difficile in adults: Treatment'
Intravenous tigecycline as adjunctive or alternative therapy for severe refractory Clostridium difficile infection.
Herpers BL, Vlaminckx B, Burkhardt O, Blom H, Biemond-Moeniralam HS, Hornef M, Welte T, Kuijper EJ
Clin Infect Dis. 2009;48(12):1732.
Clostridium difficile infection (CDI) has become more refractory to standard therapy. We describe 4 patients with severe refractory CDI who were successfully treated with tigecycline. Symptoms improved within 1 week. No relapses were observed. This favorable outcome suggests that tigecycline might be a useful alternative for treating severe refractory CDI.
Department of Medical Microbiology and Immunology, St. Antonius Hospital, PO Box 2500, Nieuwegein 3430 EM, The Netherlands. firstname.lastname@example.org