Medline ® Abstract for Reference 58
of 'Clostridium difficile in adults: Treatment'
Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species.
Credito KL, Appelbaum PC
Antimicrob Agents Chemother. 2004;48(11):4430.
Agar dilution MIC was used to compare activities of OPT-80, linezolid, vancomycin, teicoplanin, quinupristin/dalfopristin, amoxicillin/clavulanate, imipenem, clindamycin, and metronidazole against 350 gram-positive and -negative anaerobes. OPT-80 was active against gram-positive strains only, especially Clostridium spp. (85 strains tested, including 21 strains of C. difficile), with MICs ranging between</=0.016 and 0.25 microg/ml.
Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.