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Medline ® Abstract for Reference 49

of 'Clostridium difficile in adults: Treatment'

Interruption of recurrent Clostridium difficile-associated diarrhea episodes by serial therapy with vancomycin and rifaximin.
Johnson S, Schriever C, Galang M, Kelly CP, Gerding DN
Clin Infect Dis. 2007;44(6):846. Epub 2007 Feb 2.
Eight women who each experienced 4-8 episodes of Clostridium difficile-associated diarrhea were given a 2-week course of rifaximin therapy when they were asymptomatic, immediately after completing their last course of vancomycin therapy. Seven of the 8 patients experienced no further diarrhea recurrence. The patient who had a recurrence responded to a second course of rifaximin therapy, but rifaximin-resistant C. difficile was recovered after treatment. A controlled trial for treating recurrent Clostridium difficile-associated diarrhea appears to be warranted.
Loyola University Medical Center, Maywood, IL, USA. sjohnson@lumc.edu