Medline ® Abstract for Reference 23
of 'Clostridium difficile in adults: Treatment'
Efficacy of Oral Vancomycin in Preventing Recurrent Clostridium difficile Infection in Patients Treated With Systemic Antimicrobial Agents.
Van Hise NW, Bryant AM, Hennessey EK, Crannage AJ, Khoury JA, Manian FA
Clin Infect Dis. 2016 Sep;63(5):651-3.
We compared rates of recurrent Clostridium difficile infection in patients receiving or not receiving oral vancomycin prophylaxis with systemic antimicrobial therapy. The incidence of C. difficile infection was significantly lower in patients receiving prophylaxis (4.2% vs 26.6% in those without prophylaxis; odds ratio, 0.12; 95% confidence interval, .04-.4; P<.001).
Department of Pharmacy, Edward-Elmhurst Hospitals, Naperville, Illinois.