Clinical use of plasma components
- Arthur J Silvergleid, MD
Arthur J Silvergleid, MD
- Section Editor — Transfusion Medicine
- Affiliate Associate Professor, Department of Pathology and Cell Biology
- University of South Florida, College of Medicine
- Medical Director, OneBlood, Inc.
Products prepared from human plasma can be lifesaving in some conditions (eg, trauma, massive transfusion, disseminated intravascular coagulation [DIC], bleeding associated with vitamin K antagonist anticoagulation). At the same time, plasma products carry infectious and other risks. Thus, it is important to use the appropriate plasma product in the appropriate clinical setting.
This topic review will discuss available plasma products, indications and dosing for these products, and potential complications of plasma transfusion.
The use of Cryoprecipitate and plasma derivatives such as prothrombin complex concentrates (PCCs) and individual coagulation factor concentrates are discussed in separate topic reviews.
●Cryoprecipitate – (See "Clinical use of Cryoprecipitate".)
●PCCs – (See "Plasma derivatives and recombinant DNA-produced coagulation factors", section on 'Coagulation factors' and "Management of warfarin-associated bleeding or supratherapeutic INR" and "Reversal of anticoagulation in warfarin-associated intracerebral hemorrhage".)
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- PLASMA PRODUCTS
- Plasma Frozen Within 24 Hours After Phlebotomy (PF24)
- Thawed Plasma
- Liquid Plasma
- Solvent/Detergent-Treated Plasma (S/D Plasma)
- Plasma Cryoprecipitate Reduced
- Dried plasma
- Overview of indications
- Vitamin K dependent coagulation factor replacement
- Replacement of specific coagulation factors
- Minimally elevated INR
- Plasma exchange
- DOSE AND INFUSION RATE
- ABO MATCHING
- Volume overload
- Febrile and allergic reactions
- Anaphylactic reactions
- Transfusion-related acute lung injury (TRALI)
- SOCIETY GUIDELINE LINKS
- SUMMARY AND RECOMMENDATIONS