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Clinical use of Cryoprecipitate

Arthur J Silvergleid, MD
Section Editor
Steven Kleinman, MD
Deputy Editor
Jennifer S Tirnauer, MD


Cryoprecipitate (Cryoprecipitated antihemophilic factor [AHF]; cryo) is the insoluble material that comes out of solution after plasma is frozen and thawed at 4°C (between 1 and 6°C). It is rich in certain plasma proteins, especially fibrinogen.

This topic will discuss the clinical use of Cryoprecipitate. Use of other plasma products and plasma derivatives is discussed in separate topic reviews:

Fresh Frozen Plasma (FFP) and other plasma products – (See "Clinical use of plasma components".)

Plasma derivatives including coagulation factor concentrates – (See "Plasma derivatives and recombinant DNA-produced coagulation factors".)

Fibrin sealant – (See "Fibrin sealants".)


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Literature review current through: Jul 2017. | This topic last updated: Dec 12, 2016.
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