Clinical manifestations, pathologic features, and diagnosis of precursor B cell acute lymphoblastic leukemia/lymphoma
- Arnold S Freedman, MD
Arnold S Freedman, MD
- Section Editor — Lymphoproliferative Disorders
- Professor of Medicine
- Harvard Medical School
- Jon C Aster, MD
Jon C Aster, MD
- Professor of Pathology
- Harvard Medical School
In the WHO classification system for hematologic malignancies, the lymphoblastic neoplasms, which may present as leukemia and/or lymphoma, are divided into two general categories based upon lineage (see "Classification of the hematopoietic neoplasms") [1,2]:
●Precursor B cell lymphoblastic leukemia/lymphoma, also called precursor B cell acute lymphoblastic leukemia (precursor B cell ALL)
●Precursor T cell lymphoblastic leukemia/lymphoma (precursor T-LBL), also called precursor T cell acute lymphoblastic leukemia (precursor T cell ALL)
This is largely done because the prognosis and treatment differ between neoplasms of B and T cell lineage. These can be further divided into either lymphoblastic lymphoma or lymphoblastic leukemia:
●Clinically, a case is defined as lymphoma (LBL) if there is a mass lesion in the mediastinum or elsewhere and <25 percent blasts in the bone marrow.
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- CELL OF ORIGIN
- CLINICAL FEATURES
- PATHOLOGIC FEATURES
- Histochemistry and immunophenotype
- Genetic features
- - Numerical changes
- - Translocations
- - Point mutations and small indels
- - Gene expression
- DIFFERENTIAL DIAGNOSIS
- INFORMATION FOR PATIENTS