Medline ® Abstract for Reference 89
of 'Clinical manifestations of varicella-zoster virus infection: Herpes zoster'
89
TI
Disseminated varicella infection in adult renal allograft recipients: role of mycophenolate mofetil.
AU
Lauzurica R, Bayés B, Frías C, FontseréN, Hernandez A, Matas L, Jimenez A, Bonet J, Romero R
SO
Transplant Proc. 2003;35(5):1758.
Disseminated varicella zoster virus (VZV) infection is a rare complication after renal transplantation in adults. We report 4 cases diagnosed in our transplant patients. One of which was a primary infection (chicken pox) with multivisceral involvement (hepatitis, pneumonitis, myocarditis, and disseminated intravascular coagulation). The other 3 patients VZV-seropositive before transplantation suffered from disseminated zoster. No immunosuppressive drug was significantly associated with a higher risk of disseminated VZV infection. However, from our experience, we believe that mycophenolate mofetil (MMF), plays a part in the clinical presentation of the disease. Early treatment with high doses of acyclovir is fundamental in infection control. It is essential to perform a pretransplantation serological VZV study on all patients.
AD
Nephrology Department, Kidney Transplant Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. rlauzu@ns.hugtip.scs.es
PMID