Medline ® Abstract for Reference 10
of 'Clinical manifestations, differential diagnosis, and initial management of psychosis in adults'
10
TI
Initial medical work-up of first-episode psychosis: a conceptual review.
AU
Freudenreich O, Schulz SC, Goff DC
SO
Early Interv Psychiatry. 2009 Feb;3(1):10-8.
AIM:
To help clinicians carry out a comprehensive, medical diagnostic assessment in first-episode patients who are suspected of developing schizophrenia.
METHODS:
Conceptual review of the published work with emphasis on the diagnostic goals of excluding medical causes of psychosis and establishing a medical baseline.
RESULTS:
There is no agreed-upon standard for the initial medical work-up of first-episode cases. Excluding secondary causes of schizophrenia requires consideration of likelihood of disease; laboratory test performance; and relevance of positive test results.
CONCLUSIONS:
We propose a medical work-up for first-episode psychosis that combines: (i) broad screening; (ii) exclusion of specific diseases informed by treatability and epidemiology; and (iii) medical baseline measures.
AD
Massachusetts General Hospital Schizophrenia Program, Freedom Trail Clinic, Harvard Medical School, 25 Staniford Street, Boston, MA 02114, USA. ofreudenreich@partners.org
PMID