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Medline ® Abstract for Reference 44

of 'Clinical manifestations, diagnosis, and management of diabetic infections of the lower extremities'

44
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Lack of microbiological concordance between bone and non-bone specimens in chronic osteomyelitis: an observational study.
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Zuluaga AF, Galvis W, Jaimes F, Vesga O
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BMC Infect Dis. 2002;2:8. Epub 2002 May 16.
 
BACKGROUND: Prognosis of chronic osteomyelitis depends heavily on proper identification and treatment of the bone-infecting organism. Current knowledge on selecting the best specimen for culture is confusing, and many consider that non-bone specimens are suitable to replace bone cultures. This paper compares the microbiology of non-bone specimens with bone cultures, taking the last as the diagnostic gold standard.
METHODS: Retrospective observational analysis of 50 patients with bacterial chronic osteomyelitis in a 750-bed University-based hospital.
RESULTS: Concordance between both specimens for all etiologic agents was 28%, for Staphylococcus aureus 38%, and for organisms other than S. aureus 19%. The culture of non-bone specimens to identify the causative organisms in chronic osteomyelitis produced 52% false negatives and 36% false positives when compared against bone cultures.
CONCLUSIONS: Diagnosis and therapy of chronic osteomyelitis cannot be guided by cultures of non-bone specimens because their microbiology is substantially different to the microbiology of the bone.
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Section of Infectious Diseases, Department of Medicine, University of Antioquia Medical School and Hospital Universitario San Vicente de Paul, Medellín, Colombia. azuluaga@medicina.udea.edu.co
PMID