Medline ® Abstract for Reference 205
of 'Clinical manifestations and diagnosis of the myelodysplastic syndromes'
205
TI
Neutrophil dysplasia caused by mycophenolate mofetil.
AU
Banerjee R, Halil O, Bain BJ, Cummins D, Banner NR
SO
Transplantation. 2000;70(11):1608.
Two transplant recipients developed striking morphological abnormalities in their circulating neutrophils while receiving mycophenolate. The changes included nuclear hypolobulation and abnormal clumping of nuclear chromatin and were presumably related to inhibition of guanosine nucleoside synthesis. In both cases the neutrophil abnormalities preceded the development of neutropenia and were thus a sign of impending hematological toxicity. The hematological changes resolved after the drug was discontinued.
AD
Royal Brompton and Harefield Hospitals NHS Trust, Paddington, London, UK.
PMID