Medline ® Abstracts for References 40,41
of 'Clinical manifestations and diagnosis of oral allergy syndrome (pollen-food allergy syndrome)'
Allergenic cross-reactivity, food allergy and pollen.
Environ Toxicol Pharmacol. 1997;4(1-2):61.
Pollen-allergic patients frequently present oral allergy-like symptoms after ingestion of several kinds of plant foods. The majority of these reactions are due to three distinct cross-reactive structures that are present in birch pollen. Proteins that share common epitopes with Bet v 1, the major birch pollen allergen, occur in other kinds of tree pollen, apples, stone fruits, celery, carrots and nuts. Approximately 70% of patients who are allergic to birch pollen may experience symptoms after consumption of foods from these groups. In contrast to Bet v 1, two minor allergenic structures which sensitise≈10-20% of all pollen-allergic patients are also present in grass and weed pollen, namely profilin and cross-reactive carbohydrate determinants. Profilins can induce symptoms to almost all kinds of plant foods, whereas the clinical relevance of IgE binding to ubiquitous carbohydrates of N-glycans from plants remains in doubt. The paper summarises the knowledge pertaining to the molecular features of these cross-reactive structures and the characteristics of the cross-reactivity patterns and discusses aspects of diagnosis, management and routes of sensitisation.
Paul-Ehrlich-Institut, Department of Allergology, P.O. Box, D-63207 Langen, Germany.
Correlation of oral allergy syndrome due to plant-derived foods with pollen sensitization in Japan.
Maeda N, Inomata N, Morita A, Kirino M, Ikezawa Z
Ann Allergy Asthma Immunol. 2010;104(3):205.
BACKGROUND: The clinical features of patients with oral allergy syndrome (OAS) due to plant-derived foods related to pollen allergy have been rarely reported in Japan.
OBJECTIVES: To evaluate the characteristics of OAS and to investigate whether pollen sensitizations are correlated with the prevalence of OAS in Japan.
METHODS: We measured specific IgE antibodies against 5 pollens in 622 outpatients (277 males and 345 females; mean age, 37 years) with atopic dermatitis, urticaria, angioedema, and food allergy during a 2-year period. Furthermore, OAS is diagnosed based on anamnesis and positive skin prick test reactions to suspected foods.
RESULTS: Eighteen of the 436 patients (4.1%) sensitized to pollens were diagnosed as having OAS. Rates of specific IgE antibody-positive responses against Japanese cedar, ragweed, orchard grass, mugwort, and alder pollen were 69.8%, 35.3%, 29.1%, 24.1%, and 19.6%, respectively. The prevalence of OAS showed a significant positive correlation with sensitization to alder (P<.001). In addition, the most frequent causative foods were found to be apple, peach, and melon. The prevalence of OAS due to apple showed a significant positive correlation with sensitization to alder (P<.001) pollen, due to peach showed a significant positive correlation with sensitization to alder (P<.001) and orchard grass (P<.05) pollen, and due to melon showed a significant positive correlation with sensitization to alder (P<.005), orchard grass (P<.05), and ragweed (P<.05) pollen.
CONCLUSION: Sensitization to pollens from species in the Betulaceae family is most strongly implicated in causing OAS in Japan.
Department of Dermatology, Yokohama City University Hospital, Yokohama, Japan. email@example.com