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Clinical manifestations and diagnosis of hemophilia

W Keith Hoots, MD
Amy D Shapiro, MD
Section Editors
Lawrence LK Leung, MD
Donald H Mahoney, Jr, MD
Deputy Editor
Jennifer S Tirnauer, MD


Hemophilia A and B are X-linked recessive diseases that present in male children of carrier females. However, hemophilia must sometimes be differentiated from other bleeding disorders when the family history is negative or unknown. Differentiation between hemophilia and other conditions, such as some types of von Willebrand disease or acquired factor inhibitors, and distinction between hemophilia A and B are crucial for appropriate management.

The clinical manifestations and diagnosis of hemophilia A and B will be reviewed here, along with a discussion of obstetrical issues. Other issues related to care for people with hemophilia are presented separately.

Routine care including prophylaxis – (See "Hemophilia A and B: Routine management including prophylaxis".)

Treatment of bleeding and perioperative management – (See "Treatment of bleeding and perioperative management in hemophilia A and B".)

Inhibitors – (See "Factor VIII and factor IX inhibitors in patients with hemophilia".)


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