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Clinical manifestations and diagnosis of gout

Michael A Becker, MD
Section Editor
Nicola Dalbeth, MBChB, MD, FRACP
Deputy Editor
Paul L Romain, MD


Gout (monosodium urate [MSU] crystal deposition disease) is characterized biochemically by extracellular fluid urate saturation, which is reflected in the blood by hyperuricemia, with serum or plasma urate concentrations exceeding 6.8 mg/dL (approximately 400 micromol/L); this level of urate is the approximate limit of urate solubility. The clinical manifestations of gout may include:

Recurrent attacks of acute inflammatory arthritis

A chronic arthropathy

Accumulation of urate crystals in the form of tophaceous deposits

Uric acid nephrolithiasis

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Literature review current through: Nov 2017. | This topic last updated: Sep 29, 2017.
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