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Medline ® Abstract for Reference 8

of 'Clinical manifestations and diagnosis of fibromuscular dysplasia'

Renal fibromuscular dysplasia in elderly persons.
Pascual A, Bush HS, Copley JB
Am J Kidney Dis. 2005;45(4):e63.
Renal artery stenosis (RAS) is a significant cause of secondary hypertension, the progression of which can lead to renal insufficiency, uncontrolled hypertension, and even end-stage renal disease. The 2 most common forms of RAS are atherosclerotic renovascular disease and fibromuscular dysplasia (FMD). Atherosclerosis accounts for 90% of all cases of RAS and generally affects an elderly population. Conversely, FMD accounts for approximately 10% of all RAS cases and is described as affecting a younger population. Four cases of FMD in individuals older than 70 years are presented, in a period of 1 year at 1 facility. This case series calls into question the previously reported low prevalence of FMD in elderly persons. It is conceivable that renal artery investigation might be denied an elderly patient thought to have atherosclerotic disease. Because conventional angioplasty is considered the treatment of choice for patients with FMD because of the high response rate for uncontrolled hypertension, the prevalence of FMD in the elderly population should be reevaluated to detect and treat this population accordingly.
Department of Nephrology and Hypertension, Cleveland Clinic Florida, Weston, FL 33331, USA. pascuaa@ccf.org