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Medline ® Abstract for Reference 75

of 'Clinical manifestations and diagnosis of Fanconi anemia'

Oral and dental findings in Fanconi's anemia.
Açikgöz A, Ozden FO, Fisgin T, Açikgöz G, Duru F, Yarali N, Albayrak D
Pediatr Hematol Oncol. 2005 Sep;22(6):531-9.
Fanconi's anemia is an autosomal recessive disorder characterized by progressive pancytopenia and congenital malformation of the skeleton. This study investigated the oral health status of 15 children with Fanconi's anemia, including oral lesions, gingival and periodontal status, and dental abnormalities. All children in the group were found to have a tendency to develop tooth decay and were in need of dental treatment. Two had aggressive periodontitis. In one patient supernumerary teeth were found, while in another teeth were congenitally missing. The increased tendency toward periodontal disease in patients with Fanconi's anemia may be due not only to the anemia, leukopenia, and defective detoxification of oxygen radicals that are characteristic of the disease itself, but also to medications applied during intense immunosuppressive treatment, such as prednisolone.
Baskent University Faculty of Dentistry, Department of Oral Diagnosis and Radiology, Ankara, Turkey.