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Clinical manifestations and diagnosis of Chlamydia trachomatis infections

Jeanne Marrazzo, MD, MPH, FACP, FIDSA
Section Editor
Noreen A Hynes, MD, MPH, DTM&H
Deputy Editor
Allyson Bloom, MD


Chlamydia trachomatis is the most common bacterial cause of sexually transmitted genital infections [1]. The majority of affected persons are asymptomatic, and thus provide an ongoing reservoir for infection. In infants born to mothers through an infected birth canal, conjunctivitis and pneumonia can occur. Moreover, both men and women can experience clinical syndromes due to infection at common epithelial sites, including the rectum and conjunctivae. Other types of C. trachomatis infection, including lymphogranuloma venereum and endemic trachoma, an ocular infection spread by direct contact and seen commonly in the developing world, may occur in both men and women.

The clinical manifestations and diagnosis of C. trachomatis in women and men are discussed below. The epidemiology and treatment of C. trachomatis as well as neonatal C. trachomatis infection, lymphogranuloma venereum, and endemic trachoma are discussed in detail elsewhere. (See "Epidemiology of Chlamydia trachomatis infections" and "Treatment of Chlamydia trachomatis infection" and "Chlamydia trachomatis infections in the newborn" and "Lymphogranuloma venereum" and "Overview of trachoma".)

Screening for chlamydia and other sexually transmitted infections is also discussed elsewhere. (See "Screening for sexually transmitted infections".)


Although the majority of women with C. trachomatis infection are asymptomatic, the pathogen is an important cause of several common clinical syndromes, discussed below.

Genital infection — In women, the cervix is the most commonly infected anatomic site [2], and a proportion of women may also have infection of the urethra. Untreated, cervical infection can ascend to cause pelvic inflammatory disease and its sequelae of infertility and chronic pain. Pregnant women with genital chlamydial infection are also at high risk for complications.


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Literature review current through: Sep 2016. | This topic last updated: Nov 5, 2015.
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