Clinical features of multiple sclerosis in adults
- Michael J Olek, DO
Michael J Olek, DO
- Associate Professor of Neurology
- Loma Linda University Medical Center
Diseases that affect central nervous system myelin can be categorized as demyelinating (acquired, inflammatory) and dysmyelinating (abnormal formation of myelin, usually genetic basis) (table 1). The most common immune-mediated inflammatory demyelinating disease of the central nervous system is multiple sclerosis (MS).
The clinical features and disease course of MS will be reviewed here. Other aspects of MS are discussed separately:
- Rice CM, Cottrell D, Wilkins A, Scolding NJ. Primary progressive multiple sclerosis: progress and challenges. J Neurol Neurosurg Psychiatry 2013; 84:1100.
- Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011; 69:292.
- Mowry EM, Deen S, Malikova I, et al. The onset location of multiple sclerosis predicts the location of subsequent relapses. J Neurol Neurosurg Psychiatry 2009; 80:400.
- Richards RG, Sampson FC, Beard SM, Tappenden P. A review of the natural history and epidemiology of multiple sclerosis: implications for resource allocation and health economic models. Health Technol Assess 2002; 6:1.
- Balcer LJ. Clinical practice. Optic neuritis. N Engl J Med 2006; 354:1273.
- McGraw C, Krieger S, Wong J, Fabian M. The food critic who couldn't taste and 6 other cases of dysgeusia in multiple sclerosis. Neurology 2012; 78(Meeting Abstracts 1):P06.178. www.neurology.org/cgi/content/meeting_abstract/78/1_MeetingAbstracts/P06.178 (Accessed on March 10, 2015).
- Kanchandani R, Howe JG. Lhermitte's sign in multiple sclerosis: a clinical survey and review of the literature. J Neurol Neurosurg Psychiatry 1982; 45:308.
- Drulovic J, Basic-Kes V, Grgic S, et al. The Prevalence of Pain in Adults with Multiple Sclerosis: A Multicenter Cross-Sectional Survey. Pain Med 2015; 16:1597.
- Solaro C, Brichetto G, Amato MP, et al. The prevalence of pain in multiple sclerosis: a multicenter cross-sectional study. Neurology 2004; 63:919.
- Aschoff JC, Conrad B, Kornhuber HH. Acquired pendular nystagmus with oscillopsia in multiple sclerosis: a sign of cerebellar nuclei disease. J Neurol Neurosurg Psychiatry 1974; 37:570.
- Barton JJ, Cox TA. Acquired pendular nystagmus in multiple sclerosis: clinical observations and the role of optic neuropathy. J Neurol Neurosurg Psychiatry 1993; 56:262.
- Gresty MA, Ell JJ, Findley LJ. Acquired pendular nystagmus: its characteristics, localising value and pathophysiology. J Neurol Neurosurg Psychiatry 1982; 45:431.
- Selhorst JB, Saul RF. Uhthoff and his symptom. J Neuroophthalmol 1995; 15:63.
- Humm AM, Beer S, Kool J, et al. Quantification of Uhthoff's phenomenon in multiple sclerosis: a magnetic stimulation study. Clin Neurophysiol 2004; 115:2493.
- White CP, White MB, Russell CS. Invisible and visible symptoms of multiple sclerosis: which are more predictive of health distress? J Neurosci Nurs 2008; 40:85.
- CLINICAL SYMPTOMS AND SIGNS
- Visual loss
- Internuclear ophthalmoplegia
- Sensory symptoms
- Lhermitte phenomenon
- Motor symptoms
- Bowel/bladder/sexual function
- Heat sensitivity
- Paroxysmal symptoms
- Cognitive dysfunction
- INFORMATION FOR PATIENTS