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Related articles

Clinical features, laboratory manifestations, and diagnosis of multiple myeloma

INTRODUCTION

Multiple myeloma (MM) is characterized by the neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin. This clone of plasma cells proliferates in the bone marrow and often results in extensive skeletal destruction with osteolytic lesions, osteopenia, and/or pathologic fractures. The diagnosis of MM is often suspected because of one (or more) of the following clinical presentations:

Bone pain with lytic lesions discovered on routine skeletal films

An increased total serum protein concentration and/or the presence of a monoclonal protein in the urine or serum

Systemic signs or symptoms suggestive of malignancy, such as unexplained anemia

Hypercalcemia, which is either symptomatic or discovered incidentally

                                      

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Literature review current through: Sep 2014. | This topic last updated: Apr 4, 2014.
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