Medline ® Abstract for Reference 85
of 'Clinical features and diagnosis of restless legs syndrome/Willis-Ekbom disease and periodic limb movement disorder in adults'
85
TI
Restless legs syndrome and nocturnal myoclonus: initial clinical manifestation of familial amyloid polyneuropathy.
AU
Salvi F, Montagna P, Plasmati R, Rubboli G, Cirignotta F, Veilleux M, Lugaresi E, Tassinari CA
SO
J Neurol Neurosurg Psychiatry. 1990;53(6):522.
Restless legs syndrome was the first isolated clinical manifestation in four siblings of a family with familial amyloid polyneuropathy. Clinical and electrophysiological evidence of peripheral neuropathy appeared after a variable time interval. Polysomnography showed abnormal sleep patterns and nocturnal myoclonus in all patients. The restless legs syndrome responded favourably to clonazepam.
AD
Institute of Neurology, University of Bologna, Italy.
PMID